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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
1219737-12-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
| 规格： | 25 mg | 产品价格： | ￥2500.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
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MK-3903
CAS No. : 1219737-12-8
MCE 国际站：MK-3903
产品活性：MK-3903 是一种有效且有选择性的 AMP 激活的蛋白激酶 (AMPK) 激活剂，其 EC50 值为 8 nM。
研究领域：Epigenetics | PI3K/Akt/mTOR
作用靶点：AMPK
In Vitro: MK-3903 (compound 42) is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. MK-3903 activates 10 of the 12 phosphorylated AMPK (pAMPK) complexes with EC50 values in the range of 8 to 40 nM and maximal activation >50%. MK-3903 partially activates pAMPK5 (36% max) and it does not activate pAMPK6. MK-3903 demonstrates low permeability (Papp=6×10-6 cm/s) in LLC-PK1 cells42 and is a substrate of human liver uptake transporters OATP1B1 and OATP1B3 (organic anion transporter proteins). Results show that MK-3903 binds moderately to the prostanoid DP2 (CRTH2) receptor (binding IC50=1.8 μM) but not in the presence of 10% human serum (binding IC50>86 μM).
In Vivo: The pharmacokinetics of MK-3903 (compound 42) in C57BL/6 mice, Sprague to Dawley rats, and beagle dogs are characterized by moderate systemic plasma clearance (5.0 to13 mL/min/kg), a volume of distribution at steady state of 0.6 to 1.1 L/kg, and a terminal halflife of ~2h. Acute oral administration of MK-3903 (3, 10, and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses.
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文献和实验电话15309255122 QQ:1578302142 传真029-85237916 联系人 寇小姐 EPR-04 DGR-M1 MK-01P EPM-4C GKR-M2 EPM-4CT EVM-05C EPM-04 AK-01D 5A CKR-81T ECR-3 MPR-53 RG-6T-96 MK-03P EPR-03 GKRS-02F EVM-3 DGRD-01 EPM-0X FKR
from primary subcutaneous adipose tissues and the preadipocyte cell line 3T3L1. The cells are first cultured in an adipocyte induction medium for 10–12 days, followed by 8–14 days culture in a MK differentiation medium. Adipose tissue-derived MKs and platelets
1. 和各种酶标（带通讯口）仪器（ MK3, FC, Ascent, MR5000,Sunrise等）进行连接操作，并能够实现由计算机控制仪器（仪器必须具备双向通讯协议才能实现），简化了用户操作程序。 2. 定量计算支持各种试剂的计算方程，特殊应用有专用方案来处理，支持疾控重心、血站、粮食、动物检疫。 3. 定性计算，多条件的阴阳性判断公式的灵活设置，可针对实验的结果和有效性进行判断。 4.
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