Y06036,1832671-96-1

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Y06036

CAS No. : 1832671-96-1

MCE 国际站：Y06036

产品活性：Y06036 是一种有效的选择性 BET 抑制剂，可与 BRD4(1) 溴结构域结合，K_d 值为 82 nM。具有抗肿瘤活性。

研究领域：Epigenetics

作用靶点：Epigenetic Reader Domain

In Vitro: Y06036 (0.001-100 nM, 96 hours for LNCaP, C4-2B, and 22Rv1 cells; 144 hours for VCaP cells) exhibits low micromolar or nanomolar potencies (IC₅₀: 0.29-2.6 μΜ) in the four androgen receptor (AR)-positive prostate cancer cell lines LNCaP, C4-2B, 22Rv1, and VCaP. Treatment of 22Rv1 cells with Y06036 (1, 2, 4, 8, and 16 μM, 48 hours) results in significant down-regulation of both full-length (AR-fl) and AR variants levels.

In Vivo: Y06036 (50 mg/kg, i.p. injection, 5 times per week, 25 days) demonstrates therapeutic effects in a C4-2B CRPC xenograft tumor model in mice. Y06036 is well tolerated in the treated mice, based on the weight of the animal body and their general behavior.

相关产品：Bioactive Compound Library Plus  |  Epigenetics Compound Library  |  Histone Modification Research Compound Library  |  Anti-Cancer Compound Library  |  Reprogramming Compound Library  |  Anti-Blood Cancer Compound Library  |  Highly Selective Inhibitors Library  |  (+)-JQ-1  |  Curcumin  |  A-485  |  C646  |  Revumenib  |  BRM/BRG1 ATP Inhibitor-1  |  BI 2536  |  dBET6  |  MZ 1  |  ARV-825  |  Inobrodib  |  Birabresib  |  666-15  |  SGC-CBP30  |  VTP50469  |  ACBI1  |  AU-15330  |  ARV-771  |  I-BET151  |  dBET1  |  dCBP-1  |  ABBV-744  |  Anacardic Acid  |  Molibresib  |  NSC 228155  |  KG-501  |  A-366  |  FHD-286  |  Mivebresib

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds