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- 详细信息
- 技术资料
- 保存条件：
Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
FR236924
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
28399-31-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1018.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥900.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2100.0 |
| 规格： | 25 mg | 产品价格： | ￥4200.0 |
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DCP-LA
CAS No. : 28399-31-7
MCE 国际站：DCP-LA
产品活性：DCP-LA (FR236924) 是一种亚油酸衍生物，选择性地激活 PKCε。DCP-LA 能够刺激 AMP 受体胞吐，并抑制蛋白磷酸酶-1 (PP-1) 和激活 Ca(2+)/钙调素依赖性蛋白激酶 II (CaMKII)。DCP-LA 能够抑制 caspase-3/-9 激活，以保护神经元免受到氧化应激诱导的细胞凋亡的影响。
研究领域：Epigenetics | TGF-beta/Smad | Neuronal Signaling | Metabolic Enzyme/Protease | Apoptosis
作用靶点：PKC | CaMK | Phosphatase | Apoptosis
In Vitro: DCP-LA (100 nM; 15 min) activates cytosolic PKCε by binding to the phosphatidylserine binding/associating sites Arg50 and Ile89, without translocation towards the cell surface in PL-12 cells.
DCP-LA (10, 100, 100 nM; 10 min; 35 ℃) activates CaMKII and inhibits PP-1 in rat hippocampal neurons.
DCP-LA (100 nM; 20 min) increases expression of the receptors on the plasma membrane, responsible for potentiate AMPA receptor responses in rat hippocampal slices.
DCP-LA (100 nM; 10 min) results facilitation of hippocampal synaptic transmission.
DCP-LA (100 nM; 24 h) prevents the Sodium nitroprusside (SNP, HY-10219) effect and rescues neurons from SNP-induced degradation.
DCP-LA (100 nM; 12 h) abolishes the caspase-3/9 activation induced by (SNP, HY-10219) (1 mM).
In Vivo: DCP-LA (1 mg/kg; p.o.; once daily; 7 d) exhibits a protective effect against ischemic brain damage, decreasing cerebral cortical defect due to middle cerebral artery (MCA) occlusion in mouse model.
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