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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
939981-37-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1647.0 |
| 规格： | 5 mg | 产品价格： | ￥3625.0 |
| 规格： | 10 mg | 产品价格： | ￥5800.0 |
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p53 and MDM2 proteins-interaction-inhibitor (chiral)
CAS No. : 939981-37-0
MCE 国际站：p53 and MDM2 proteins-interaction-inhibitor (chiral)
产品活性：手性p53 and MDM2 proteins-interaction-inhibitor是p53和MDM2相互作用的抑制剂。
研究领域：Apoptosis | Metabolic Enzyme/Protease
作用靶点：MDM-2/p53 | E1/E2/E3 Enzyme
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文献和实验IB TAT [58] p16 TAT [59] Caspase 3 TAT [60] Cre recombinase FGF-4 [61] p53 TAT [62] p73 TAT [62] Cdk2 TAT [63] E2F-1 TAT [62] aAll peptides and proteins were prepared as fusion constructs between thepeptide
Studies of the Ubiquitin Proteasome System
Materials Adherent cells expressing the substrate protein and E3 of interest (e.g., U2OS cells for p53 and MDM2), growing in 100‐mm dishes 50 mM MG132 (Calbiochem, Boston Biochem, or Biomol) in DMSO
了一种新型含有四氢吡咯环的杂环肽。见（Figure 8）。 John PM[18]等人也通过侧锚定的方法合成了一种能够抑制p53-MDM2活性的复杂环肽。由于p53是一种介导细胞修复增殖具有抑制肿瘤活性的蛋白质因子，而MDM2则可以和p53的DNA结合从而抑制p53的表达。所以能够抑制MDM2与p53DNA结合的物质有可能具有抑癌活性。因此，该环肽的化学合成成功引起了广泛的关注。 Figure 8. Synthesis of a Mannich-base hybridized
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