Amelubant,346735-24-8

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Amelubant

CAS No. : 346735-24-8

MCE 国际站：Amelubant

产品活性：Amelubant (BIIL 284) 是一种有效、可口服、长效的 LTB₄ receptor 拮抗剂，对 LTB₄ 受体的结合亲和性很低，在细胞和细胞膜中，K_i 值分别为 221 nM 和 230 nM。Amelubant (BIIL 284) 是活性代谢物 BIIL 260 和 BIIL 315 的前体。具有抗炎活性。

研究领域：GPCR/G Protein

作用靶点：Leukotriene Receptor

In Vitro: Amelubant is a prodrug of active metabolites BIIL 260 and BIIL 315, which are reversible and competitive LTB₄ receptor antagonists, with K_is of 1.4, 1.1 nM and 1.7, 1.9 nM in vital cells and membranes, respectively.

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