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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
4°C, protect from light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1142214-62-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3397.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1363.0 |
| 规格： | 5 mg | 产品价格： | ￥3000.0 |
| 规格： | 10 mg | 产品价格： | ￥4800.0 |
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AM-1638
CAS No. : 1142214-62-7
MCE 国际站：AM-1638
产品活性：AM-1638是有效，有口服活性的 GPR40/FFA1 激动剂，EC50 值为0.16 μM。
研究领域：GPCR/G Protein
In Vivo: AM-1638 exhibits moderate cross-species plasma clearance and volume of distribution, resulting in plasma half-lives suitable for evaluation of its antidiabetic properties in mouse, rat, and cynomologus monkey. Moreover, oral administration of full agonist AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%). AM-1638exhibits antidiabetic activity in BDF/DIO mice.
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文献和实验-aminolevulinic acid-induced oxidative cell damage JOURNAL Biochim. Biophys. Acta 1638 (2), 173-178 (2003) PUBMED 12853123 REFERENCE 42 (bases 1 to 1600) AUTHORS Tsui,T.Y., Wu,X., Lau,C.K., Ho,D.W., Xu,T., Siu,Y.T. and Fan,S.T. TITLE Prevention of chronic
., Sestan, N., Lifton, R.P., State, M.W., and Günel, M. 2010. Whole‐exome sequencing identifies recessive WDR62 mutations in severe brain malformations. Nature 467:207‐210. Borge
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