LCB-2853,141335-10-6

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LCB-2853

CAS No. : 141335-10-6

MCE 国际站：LCB-2853

产品活性：LCB-2853 是 thromboxane A2 受体的拮抗剂，具有抗血小板和抗血栓的作用。

研究领域：GPCR/G Protein

作用靶点：Prostaglandin Receptor

In Vivo: In dog coronary stenosis, LCB 2853 shows a very high efficacy with ED₅₀ of 7.2 μg/kg. In rat venous thrombosis induced by combination of venous injury and blood stasis, perfused LCB 2853 decreases the weight of thrombi in a dose related manner with ED₅₀ of 220 μg/kg/min. In vivo, both against platelet aggregation and vasoconstriction, LCB 2853 shows an ED₅₀ lower than 1 mg/kg i.v. in rat AA-induced thrombocytopenia or U 46619-induced hypertension (ED₅₀ = 0.25 and 0.16 mg/kg) as well as in AA-induced sudden death in the mouse (ED₅₀ = 0.44 mg/kg). The U 46619-induced bronchoconstriction is blocked after i.v. administration of LCB 2853 (ED₅₀ = 18.4 μg/kg).

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