- ￥409 - 6000
- MedChemExpress(MCE)
- 美国
- HY-100882
- 2025年12月04日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
638132-34-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥914.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥409.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1350.0 |
| 规格： | 25 mg | 产品价格： | ￥2700.0 |
| 规格： | 50 mg | 产品价格： | ￥4050.0 |
| 规格： | 100 mg | 产品价格： | ￥6000.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
ONO-7300243
CAS No. : 638132-34-0
MCE 国际站：ONO-7300243
产品活性：ONO-7300243 是一种新型有效的溶血磷脂酸受体 1 (LPA1) 拮抗剂，IC50 为 0.16 μM。
研究领域：GPCR/G Protein
作用靶点：LPL Receptor
In Vitro: ONO-7300243 shows modest in vitro activity (IC50=0.16 μM). ONO-7300243 exhibits almost identical levels of antagonist activity in vitro.
In Vivo: ONO-7300243 shows good efficacy in vivo. The oral dosing of 17a at 30 mg/kg leads to reduced intraurethral pressure in rats. ONO-7300243 shows stronge effects in vivo (88% inhibition at 10 mg/kg i.d., 62% inhibition at 3 mg/kg i.d.) compared with compound 12g. The results reveal that ONO-7300243 shows good membrane permeability and good metabolic stability against rat liver microsomes (MS). ONO-7300243 exhibits good selectivity towards LPAl over LPA2, most likely because low molecular weight and low lipophilicity lead to reduced compound promiscuity and increased selectivity. ONO-7300243 inhibits the LPA-induced IUP increase in a dose dependent manner (ID50=11.6 mg/kg p.o.) up to 1 h after dosing. Significant effects are observed at 10 and 30 mg/kg (p<0.05 vs.vehicle). ONO-7300243 (30 mg/kg, p.o.) leads to a significant decrease in the IUP in conscious rats without LPA stimulation compared with the vehicle without affecting the mean blood pressure (MBP). The results of a rat pharmacokinetic study of ONO-7300243 show that this material had a rapid clearance (CLtot=15.9 mL/min/kg at 3 mg/kg i.v.) and a short half-life (0.3 h).
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Anti-Cardiovascular Disease Compound Library | Targeted Diversity Library | Anti-Pulmonary Fibrosis Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Fingolimod hydrochloride | Sphingosine-1-phosphate | MK-571 sodium | Siponimod | Poloxamer 407 | Ki16425 | JTE-013 | Ozanimod | PF-543 Citrate | BMS-986020 | 1-Oleoyl lysophosphatidic acid sodium | BMS-986278 | SEW2871 | Etrasimod | Ponesimod | SLF1081851 | AM966 | TY-52156 | AM095 | W146 TFA | CAY10444 | CYM50358 | AS2717638 | CYM-5520 | CRT0273750 | CYM-5541 | CYM5442
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验来源的血管类器官培养方案【3】 细胞来源 hPSCs 培养试剂配方 hPSCs 培养基 中胚层分化培养基 中胚层分化培养基-2 StemPro-34 SFM 完全培养基 Collagen I 溶液 血管分化培养基 近岸蛋白产品货号 基础培养基 DMEM-F12 50％DMEM-F12 50％DMEM-F12 StemPro-34 SFM DMEM-F12 StemPro-34 SFM - 50％
development of immunogold-labelled antibodies for light microscopy. Histochemistry, 1986;85:209～214 9.De, waele M, et al. An immunogold-silver staining method for detection of cell surface antigens in ligh microscopy. J Histochem cytochem,1986;34:935
DTIAJMAEmwASYgEIJsPChUNw8GBNgAkyACTABJsDCB78HmAATYAJMgAkwAYUSYOFDobh5MCbABJgAE2ACTICFD34PMAEmwASYABNgAgolwMKHQnHzYEyACTABJsAEmAALH/weYAJMgAkwASbABBRKgIUPheLmwZgAE2ACTIAJMAEWPvg9wASYABNgAkyACSiUAAsfCsXNgzEBJsAEmAATYAIsfPB7gAkwASbABJgAE1AoARY+FIqbB2MCTIAJMAEmwARY+OD
技术资料暂无技术资料 索取技术资料
