- ￥1000 - 4000
- MedChemExpress(MCE)
- 美国
- HY-16785
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
INXN-1001; RG-115932
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1093130-72-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2750.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1000.0 |
| 规格： | 5 mg | 产品价格： | ￥2500.0 |
| 规格： | 10 mg | 产品价格： | ￥4000.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Veledimex
CAS No. : 1093130-72-3
MCE 国际站：Veledimex
产品活性：Veledimex (INXN-1001) 是昆虫蜕皮激素蜕皮激素的合成类似物，是一种具有口服活性的用于专有的基因治疗启动子系统的激活配体。Veledimex 可利用蜕皮激素受体 (EcR) 诱导基因调控系统RheoSwitch研究系统 (RTS) 激活某些基因。Veledimex 可透过在原位 GL-261 小鼠和食蟹猴的血脑屏障 (BBB)。
作用靶点：Interleukin Related
In Vivo: Veledimex (INXN-1001) generally has moderate to low oral bioavailability after a single oral administration in mice and monkeys (-56% in mice and up to 17.4% in cynomolgus monkeys) with mostly low plasma clearance (1399 and 1170 mL/h per kilogram in mice and monkeys, respectively), high volume of distribution (20271 and 9180 mL/h per kilogram in mice and monkeys, respectively), and long terminal half-lives (-10 hours in mice and -30 hours in monkeys) after intravenous administration. Ad-RTS-mIL-12 + Veledimex have demonstrated a dose-related increase in tumor IL-12 mRNA and IL-12 protein expression. Discontinuation of Veledimex resulted in a return to baseline IL-12 mRNA and protein expression in numerous syngeneic mouse tumor models. Veledimex crosses the blood-brain-barrier in both naive and orthotopic GL-261 mice with increased brain tissue level of -6 fold observed in tumor bearing vs. normal mice. Ad-RTS-mIL-12 + veledimex demonstrate a dose-related increase in survival without significant adverse events.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Angiogenesis-Related Compound Library | Targeted Diversity Library | Rare Diseases Drug Library | Resatorvid | Disulfiram | Polyinosinic-polycytidylic acid | Deucravacitinib | Raleukin | Apilimod | Tocilizumab | Oxidopamine hydrobromide | Dupilumab | Theophylline | LMT-28 | Secukinumab | Clofazimine | Benzbromarone | Sodium metatungstate | Hydrocortisone hemisuccinate | SC144 | Diacerein | Muscone | JTE-607 | Ixekizumab | IL-17A inhibitor 1 | APY0201 | Vidofludimus | Prednisone acetate | Semapimod tetrahydrochloride | ODN 2216 | Triamcinolone
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
