H-151,941987-60-6

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H-151

CAS No. : 941987-60-6

MCE 国际站：H-151

产品活性：H-151 是一种有效，选择性和共价的 STING 拮抗剂，在体外和体内均具有显着的抑制活性。H-151 减少 TBK1 磷酸化并抑制 STING 棕榈酰化。H-151 可用于自身炎症性疾病的研究。

研究领域：Immunology/Inflammation

作用靶点：STING

In Vitro: H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
?H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
?H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.

In Vivo: H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.
?H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1^?/? mice that expressed a bioluminescent IFNβ reporter.
?H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.

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