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- 2025年12月05日
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- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
53251-94-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥400.0 |
| 规格： | 10 mg | 产品价格： | ￥550.0 |
| 规格： | 25 mg | 产品价格： | ￥700.0 |
| 规格： | 50 mg | 产品价格： | ￥900.0 |
| 规格： | 100 mg | 产品价格： | ￥1170.0 |
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Pinaverium bromide
CAS No. : 53251-94-8
MCE 国际站：Pinaverium bromide
产品活性：Pinaverium bromide 是一种对胃肠道具有选择性的 L 型 钙通道 阻滞剂，能有效缓解疼痛、腹泻和肠道不适，对肠易激综合征 (IBS) 具有有良好的研究效果。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Calcium Channel
In Vitro: Pinaverium bromide (0-30 μM, 24 h) inhibits GM-CSF or CXCL1/CXCL2 induced neutrophil migration, and inhibits ROS production in the presence of 0.1 ng/mL GM-CSF in purified neutrophils from mouse bone marrow.
Pinaverium bromide (3 μM, 16 h) inhibits the GM-CSF induced expression of cytokines (IL-1β, IL-6, and TNF-α) in primed neutrophils from mouse bone marrow.
Pinaverium bromide inhibits the contractile response to ACh or KCl in the control or stressed colonic circular muscle, with IC50s of 1.66 and 0.91 μM respectively.
In Vivo: Pinaverium bromide (1-10 mg/kg, i.p.) inhibits excessive systemic inflammation in Lipopolysaccharide (HY-D1056)-induced mice.
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