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- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
CV-4093
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
89226-75-5
- 规格：
10 mM * 1 mL/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥495.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥450.0 |
| 规格： | 100 mg | 产品价格： | ￥765.0 |
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Manidipine dihydrochloride
CAS No. : 89226-75-5
MCE 国际站：Manidipine dihydrochloride
产品活性：Manidipine dihydrochloride 是一种第三代、亲脂性、口服有效且高血管选择性的钙通道 (calcium channel) 拮抗剂 (IC50 = 2.6 nM, 于豚鼠心室细胞中) 与抗高血压剂。Manidipine 能有效降低血压，兼具提高胰岛素敏感度，肾脏保护和抗动脉粥样硬化活性。Manidipine 还发挥出由 NF-κB 介导的抗炎活性以及通过抑制钙通道对多种黄病毒和负链 RNA 病毒具备的抗病毒活性。美尼地平被广泛应用于心血管、代谢性疾病和感染的研究。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | NF-κB
作用靶点：Calcium Channel | NF-κB
In Vitro: Manidipine dihydrochloride (1 μM, 42 h) suppresses IL-6 secretion in lipoproteins-induced HUVEC.
Manidipine dihydrochloride (1 μM, 16 h) suppresses IL-6 secretion in 10 ng/mL IL-1, 10 ng/mL IFN-γ, and 25 ng/mL TNFα treated THP-I .
Manidipine dihydrochloride (20 mg/mL, 48/20 h) inhibits propagation/genome replication of SFTSV (a negative-strand RNA virus) in SW13 cells.
Manidipine dihydrochloride (20 mg/mL, 48 h) interferes SFTSV N-induced inclusion body formation in Huh-7 cells.
In Vivo: Manidipine dihydrochloride (10 mg/kg, i.p., b.i.d. at day 4, day 5) prolongs survival in SFTSV-infected mice.
Manidipine dihydrochloride (25 mg/kg, i.p., b.i.d. for 2 d, then daily for 19 d) protects mice from JEV infection.
Manidipine dihydrochloride (3 mg/kg, i.g., once per day, 7 d) prevents isoproterenol-induced left ventricular hypertrophy in rats.
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for each d12 mm coverslip, 25 µl for square coverslip and 50µl for full size coverslip• Seal the coverslip with nail polish• Store in 4 C up to 2 weeksDAPI stock• 4’, 6-Diamidino-2-phenylindole dihydrochloride hydrate (DAPI) from Sigma (Cat# D-9542), 1 mg 1mg
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