CMI-392

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CMI-392

CAS No. : 205654-37-1

MCE 国际站：CMI-392

产品活性：CMI-392是一种双重 5-lipoxygenese 抑制剂和血小板活化因子 (PAF) 受体拮抗剂，IC₅₀ 值分别为100和10 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Lipoxygenase

In Vivo: Topical treatment of CMI-392 in the acute and chronic TPA models result in a significant decrease of ear weight, inflammatory cell infiltration, and histological examination. The ED₅₀ for PAF-induced mouse hemoconcentration and arachidonic acid-induced mouse ear edema are 2.2 and 1.8 mg/kg, respectively.

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