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- 2025年07月08日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AA 861
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4950.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2045.0 |
| 规格： | 5 mg | 产品价格： | ￥4500.0 |
| 规格： | 10 mg | 产品价格： | ￥7500.0 |
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Docebenone
CAS No. : 80809-81-0
MCE 国际站：Docebenone
产品活性：Docebenone (AA 861) 是一种有效的、选择性的和有口服活性的 5-脂氧合酶 (5-LO) 抑制剂。
研究领域：Metabolic Enzyme/Protease | Apoptosis
作用靶点：Lipoxygenase | Ferroptosis
In Vitro: Treatment of trichomonads with the 5-LO inhibitor Docebenone, significantly inhibits the ability of trichomonads to secrete LTB4 compared to results for trichomonads treated with medium. Docebenone strongly abolishes the stimulatory effect of TvSP on IL-8 production. Docebenone at 10-200 μM increases [Ca2+]i concentration dependently.
In Vivo: Docebenone might protect experimental acute necrotizing pancreatitis in rats. Docebenone suppresses the release of SRS-A by 55-97%, dose-dependently in doses of 10-8-10-5 M in monkeys. The antigen-induced SRS-A release from these fragments is dose dependently inhibited by 25-93% of Docebenone, with doses of 10-8-10-5 M.
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