- ￥306 - 4100
- MedChemExpress(MCE)
- 美国
- HY-17406
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Ro 40-7592
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥336.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥306.0 |
| 规格： | 10 mg | 产品价格： | ￥515.0 |
| 规格： | 25 mg | 产品价格： | ￥860.0 |
| 规格： | 50 mg | 产品价格： | ￥1234.0 |
| 规格： | 100 mg | 产品价格： | ￥1626.0 |
| 规格： | 200 mg | 产品价格： | ￥2280.0 |
| 规格： | 500 mg | 产品价格： | ￥4100.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Tolcapone
CAS No. : 134308-13-7
MCE 国际站：Tolcapone
产品活性：Tolcapone (Ro 40-7592) 是一种选择性，有效的，具有口服活性的外周和中枢 COMT 抑制剂，在肝脏中对 COMT 的 IC50 为 773 nM。Tolcapone 还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂。Tolcapone 诱导氧化应激导致神经母细胞瘤细胞凋亡(apoptosis) 和抑制肿瘤生长。
研究领域：Metabolic Enzyme/Protease | Neuronal Signaling | Apoptosis
作用靶点：COMT | Amyloid-β | Apoptosis
In Vitro: Tolcapone is cytotoxic to neuroblastoma (NB) cells with IC50 values ranging from 32.27 μM for SMS-KCNR cells to 219.8 μM for MGT9-102-08 primary cells.
?Tolcapone (25, 50,75, 100 μM) treatment activates downstream apoptotic events in NB cells. Tolcapone induces caspase-mediated apoptosis in neuroblastoma.
In Vivo: Tolcapone (125 mg/kg; orally) inhibits tumor growth and prolongs survival in vivo. There are no adverse events or differences in weight or behavior noted in the mice.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Neuronal Signaling Compound Library | FDA-Approved Drug Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Oxygen Sensing Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | Orally Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Drug-Induced Liver Injury (DILI) Compound Library | Anti-Parkinson's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Targeted Diversity Library | Rare Diseases Drug Library | EMA-Approved Drug Library | FDA-Approved Anticancer Drug Library | Human Metabolite Library | Withdrawn Drug Compound Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Mitochondrial Toxicity Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | LY294002 | Tamoxifen | Paclitaxel | Y-27632 | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | SB-431542 | Actinomycin D | Deferoxamine mesylate | Bortezomib | 5-Fluorouracil | Trametinib | Sorafenib | Oxaliplatin | Gemcitabine | Temozolomide | Rotenone | Mdivi-1 | Elesclomol | Ruxolitinib | Decitabine | SP600125 | MK-2206 dihydrochloride | Etoposide | Monomethyl auristatin E
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验多巴的辅助药物。儿茶酚对甲基转移酶(COMT)抑制剂如托卡朋(tolcapone)与entacapone，能阻滞多巴胺的降解，看来可作为左旋多巴有用的辅助药物。心得安偶尔对某些病例中出现的动作性震颤或意向性震颤有用。 外科治疗 通过立体定向切除苍白球的后腹侧部(苍白球切开术)可显著改善"关"状态下的动作过缓以及左旋多巴诱发的动作困难。在某些病例中病情的改善在术后持续长达4年。对苍白球或丘脑底核进行高频电刺激看来很有希望。对丘脑中间腹核进行深部电刺激治疗帕金森病震颤或原发性震颤可能有效。这些治疗
技术资料暂无技术资料 索取技术资料
