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- 保存条件：
Please store the product under the recommended conditions in the Certificate of Analysis.
- 英文名：
Ro 46-6240 hydrate; Ro 46-6240/010 hydrate
- 库存：
货期：电询
- 供应商：
MedChemExpress LLC
- 规格：
电询
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Napsagatran hydrate
CAS No. : 159668-20-9
MCE 国际站：Napsagatran hydrate
产品活性：Napsagatran hydrate 是一种新型的特异性凝血酶 (thrombin) 抑制剂。
研究领域：Metabolic Enzyme/Protease
作用靶点：Thrombin
In Vitro: Napsagatran (Ro 46-6240), the selective thrombin inhibitor, induces a dose-dependent prolongation of the activated partial thromboplastin time (aPTT) and prothrombin time (PT) that is evident 15 min after administration of the bolus of Napsagatran. Napsagatran also reduces the time to reperfusion in a dose-dependent manner and delays or prevents reocclusion. The decreasing intracellular amount and efflux of compound from the cells into the medium is measured. The measured CLint,efflux values are 0.13±0.06, 3.2±0.6, 10.1±2.3, and 110±2.8 for Digoxin, Fexofenadine, Napsagatran, and Rosuvastatin, respectively, thus representing drugs with a >800-fold range of efflux rates.
In Vivo: After the first hour of drug administration (from 0 to 60 min), the incorporated radioactivity into thrombi increased from baseline by 73±13, 67±22 and 32±10% in placebo, AP-1 and Napsagatran-treated rabbits, respectively. Statistical analysis confirm that thrombus growth in the placebo and AP-1 treated rabbits is not different. In contrast, reduction of 125I-fibrinogen incorporation by Napsagatran is statistical different from the placebo group (P<0.01).
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文献和实验Partial proteolysis with Staph. aureus V8 protease
mm (which is the size of the 28-tooth comb wells). Rehydrate the gel pieces in 100 microliters of rehydration/overlay buffer for 1-2 min. Do not over-hydrate. The pieces will become too fragile and will fragment. Place the gel pieces
enzyme immobilization method that overcomes the foresaid limitations. It is based on the specific interaction between His-tagged enzyme and single-walled carbon nanotubes modified with N α ,N α -bis(carboxymethyl)-l -lysine hydrate. This method
for each d12 mm coverslip, 25 µl for square coverslip and 50µl for full size coverslip• Seal the coverslip with nail polish• Store in 4 C up to 2 weeksDAPI stock• 4’, 6-Diamidino-2-phenylindole dihydrochloride hydrate (DAPI) from Sigma (Cat# D-9542), 1 mg 1mg
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