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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
N-(p-Amylcinnamoyl) anthranilic acid; ACA
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥825.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥750.0 |
| 规格： | 50 mg | 产品价格： | ￥1200.0 |
| 规格： | 100 mg | 产品价格： | ￥2100.0 |
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N-(p-amylcinnamoyl) Anthranilic Acid
CAS No. : 110683-10-8
MCE 国际站：N-(p-amylcinnamoyl) Anthranilic Acid
产品活性：N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 是一种广谱磷脂酶 A2 (PLA2) 的抑制剂，TRP channel的阻滞剂。N-(p-amylcinnamoyl) Anthranilic Acid (ACA) 也是一种有效的钙离子激活氯通道 (calcium-activated chloride channels) 的可逆抑制剂，有潜力用于心律失常的相关研究。
研究领域：Metabolic Enzyme/Protease | Neuronal Signaling | Membrane Transporter/Ion Channel
作用靶点：Phospholipase | TRP Channel
In Vitro: N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H2O2-induced Ca2+ signals (IC50=1.7 μM) in HEK293cells transfected with human TRPM2.
?N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells.
?N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA22 inhibition.
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