MLT-748,1832578-30-9

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MLT-748

CAS No. : 1832578-30-9

MCE 国际站：MLT-748

产品活性：MLT-748 是一种有效、选择性的 MALT1 的别构抑制剂，与 MALT1 的别构 Trp580 口袋结合，IC₅₀ 值为 5 nM。

研究领域：Metabolic Enzyme/Protease  |  NF-κB

作用靶点：MALT1

In Vitro: MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (K_d, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (K_d, 42 nM).
MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S, with an EC₅₀ of 69 nM.
MLT-748 (2 μM, 24 hours) increases the phosphorylation of p65 and IκBα in MALT1^mut/mut patient immortalized B cells.

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