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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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| 规格： | 1 mg | 产品价格： | ￥1364.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥3000.0 |
| 规格： | 10 mg | 产品价格： | ￥4800.0 |
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NAMPT inhibitor-linker 2
CAS No. : 2241014-82-2
MCE 国际站：NAMPT inhibitor-linker 2
产品活性：NAMPT inhibitor-linker 2 为 ADC 的一部分，由一种 NAMPT 的抑制剂作为有效载荷和一个连接物组成。ADC-4 由一个 NAMPT inhibitor-linker 2 和一个 anti-c-Kit 单克隆抗体组成，对表达 c-Kit 的细胞具有抑制作用，比如 GIST-T1 和 NCI-H526 细胞，IC50 值分别为 <7 pM 和 40 pM。
研究领域：Metabolic Enzyme/Protease | Antibody-drug Conjugate/ADC Related
作用靶点：NAMPT | Drug-Linker Conjugates for ADC
In Vitro: ADC-4 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <7 pM and 40 pM, respectively.
ADC-4 (0.01 nM-10 nM, 144 hours) inhibits cell proliferation of GIST-T1 cells, but does not affect the cell cycle.
In Vivo: ADC-4 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells.
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文献和实验Methods for Studying the Interaction of Barnase with Its Inhibitor Barstar
inside the cell. The three-dimentional structures of barnase and barstar are known both from X-ray crystallography and NMR spectroscopy (1 –4 ). The crystal structure of the complex of barnase with the barstar (C40A/C82A) double mutant has been solved by Guillet
Ribonuclease A (RNase A), DNase-free
are approximately equivalent to 1 Kunitz unit (8).Specific Activity>5000 u/mg protein (>100 Kunitz units/mg protein).Storage Buffer The enzyme is supplied in: 50 mM Tris-HCl (pH 7.4) and 50% (v/v) glycerol.Inhibition and InactivationInhibitors: the most potent inhibitor
Nested RT-PCR for Hepatitis C from Paraffin Sections
(upstream) ACTTCTGCAAACTCAGCTTTGGG (downstream) Second Round Primers: Hepatitis C (82 bp) CTCCCCTGTGAGGAACTAC (upstream) GGTCCTGGAGGCTGCACA (downstream) Albumin mRNA (151 bp) ATAAAGCTGCCTGCCTGTTG (upstream) AATCTCTGGCTCAGGCGAG (downstream
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