NCT-506,2231098-99-8

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NCT-506

CAS No. : 2231098-99-8

MCE 国际站：NCT-506

产品活性：NCT-506 是一种口服生物可利用的醛脱氢酶 1A1 (ALDH1A1) 抑制剂，IC₅₀ 为 7 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Aldehyde Dehydrogenase (ALDH)

In Vitro: NCT-506 inhibits ALDH1A1, hALDH1A3, hALDH2 with IC₅₀s of 0.007±0.001, 16.4±3.99, and 21.5 μM, respectively.
NCT-506 (100, 10, 1, 0.1 μM, 6 days) decreases significantly cell viability with an EC₅₀ of 45.6 μM in OV-90 cells. NCT-506 inhibits MIA PaCa-2, OV-90, and HT-29 cells with IC₅₀s of 0.077±0.040, 0.161±0.038, and 0.048±0.022 μM in aldefluor cell-based assays, respectively.
NCT-506 is treated in combined with Paclitaxel, IC₅₀s of 1202, 924, 870, 411, 102, and 31.8 nM with concentrations of NCT-506 at 0 (DMSO), 1, 3, 10, 20, 30 μM in SKOV-3-TR cells, respectively.

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