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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- 规格：
10 mM * 1 mL/10 mg/25 mg/50 mg/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥193.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥176.0 |
| 规格： | 25 mg | 产品价格： | ￥388.0 |
| 规格： | 50 mg | 产品价格： | ￥660.0 |
| 规格： | 100 mg | 产品价格： | ￥990.0 |
| 规格： | 200 mg | 产品价格： | ￥1700.0 |
| 规格： | 500 mg | 产品价格： | ￥3700.0 |
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DKM 2-93
CAS No. : 65836-72-8
MCE 国际站：DKM 2-93
产品活性：DKM 2-93是相对选择性的UBA5抑制剂，IC50值为430 μM。
研究领域：Metabolic Enzyme/Protease
作用靶点：E1/E2/E3 Enzyme
In Vitro: Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC50s of 90 and 30 μM, respectively.
In Vivo: DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
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