DMU2139,1821143-80-9

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

DMU2139

CAS No. : 1821143-80-9

MCE 国际站：DMU2139

产品活性：DMU2139 是有效的特异性细胞色素 P4501B1 (CYP1B1) 的抑制剂，其对 CYP1B1 和 CYP1A1 的 IC₅₀ 值分别为 9 nM，795 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Cytochrome P450

In Vitro: DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC₅₀ is reversed back to 8.3 μM from 61 μM (seen in CYP1B1-expressing cells without any inhibitor). The EC₅₀ value, in the presence of DMU2139, resembles the EC₅₀ of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein.

相关产品：Bioactive Compound Library Plus  |  Metabolism/Protease Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Antioxidant Compound Library  |  Oxygen Sensing Compound Library  |  Mitochondria-Targeted Compound Library  |  Targeted Diversity Library  |  Heterocyclic Compound Library  |  Highly Selective Inhibitors Library  |  Verapamil  |  Apigenin  |  Fenofibrate  |  Chlorpromazine hydrochloride  |  Ketoconazole  |  1-Aminobenzotriazole  |  Letrozole  |  Abiraterone  |  Itraconazole  |  Cepharanthine  |  Quinidine (15% dihydroquinidine)  |  Diosmetin  |  Clarithromycin  |  Naringin  |  Gemfibrozil 1-O-β-glucuronide  |  Atovaquone  |  Fomepizole  |  Talarozole  |  Cobicistat  |  Salvianolic acid C  |  Hypericin  |  Methoxsalen  |  Sulfaphenazole  |  (S)-Mephenytoin  |  Furafylline  |  Anastrozole  |  Gemfibrozil

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds