- ￥800 - 6000
- MedChemExpress(MCE)
- 美国
- HY-100639
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1845.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥800.0 |
| 规格： | 5 mg | 产品价格： | ￥2000.0 |
| 规格： | 10 mg | 产品价格： | ￥3500.0 |
| 规格： | 25 mg | 产品价格： | ￥6000.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Roflumilast N-oxide
CAS No. : 292135-78-5
MCE 国际站：Roflumilast N-oxide
产品活性：Roflumilast N-oxide 是一个 PDE 4 型抑制剂。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phosphodiesterase (PDE)
In Vitro: Roflumilast N-oxide at 2 nM partly mitigates the cigarette smoke extract (CSE)-induced epithelial to mesenchymal transition (EMT) in WD-HBEC in vitro. Roflumilast N-oxide (2 nM) reverses the compromised expression of E-cadherin transcripts following CSE by 45%. The expression of collagen type I is abrogated by Roflumilast N-oxide (2 nM). The epithelial cell phenotype appears protected when cells are co-incubated with Roflumilast N-oxide (2 nM). Pre-incubation with Roflumilast N-oxide (2 nM) also partly attenuates the nuclear translocation of β-catenin.
In Vivo: Single treatment of db/db mice with 10 mg/kg Roflumilast N-oxide enhances plasma glucagon-like peptide-1 (GLP-1) 4-fold. Chronic treatment of db/db mice with Roflumilast N-oxide at 3 mg/kg shows prevention of disease progression. Roflumilast-N-oxide abolishes the increase in blood glucose, reduces the increment in HbA1c by 50% and doubles fasted serum insulin compare with vehicle, concomitants with preservation of pancreatic islet morphology. Furthermore, Roflumilast-N-oxide amplifies forskolin-induced insulin release in primary islets. Roflumilast-N-oxide also shows stronger glucose-lowering effects than its parent compound.
相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-diabetic Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Alzheimer's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Colorectal Cancer Compound Library | Human Metabolite Library | Heterocyclic Compound Library | Off-patent Drug Library | IBMX | Bucladesine sodium | Rolipram | Roflumilast | Sildenafil | Theophylline | Dipyridamole | Icariin | Apremilast | Milrinone | Tadalafil | Ziritaxestat | ITI-214 | Zatolmilast | EHNA hydrochloride | Cilostazol | Pentoxifylline | PF-8380 | Ro 20-1724 | Ibudilast | Cilostamide | W-7 hydrochloride | Crisaborole | Nerandomilast | Edelinontrine | Butein | Mardepodect | PF-04957325
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验高脂饮食的危害又添实锤！用这种方式悄悄影响你的心脏，一种肠炎
导读高脂肪饮食通常与心血管疾病有关，部分原因是高脂肪饮食中富含胆碱，而胆碱会被肠道微生物转化为三甲胺（Trimethylamine, TMA）。TMA 在肠道中被吸收后转运到肝脏中，进而被氧化为 TMAO（Trimethylamine N-oxide），TMAO 则是一种促进动脉粥样硬化的代谢产物。不过，TMAO 生成途径中仍然存在一个关键但尚未探索的难题：高脂肪饮食下宿主生理和微生物群落之间的相互作用是如何影响 TMAO 产生的？专性厌氧梭菌科（厚壁菌门）和兼性厌氧肠杆菌科（变形菌门）中普遍
with 5-diethoxylphosphoryl-5-methyl-1-pyrroline N -oxide (DEPMPO), indicating that FMN/FMN-binding domain (complex I), ubiquinone (complex I and III), FAD/FAD-binding domain (complex II), and cytochrome b (complex III) control the mediation of O2 •– production
Crystallization of Kinesin Family Motor Proteins
Kar3+N11 (WT)PDB: 1F9TP21a=43.6 Åb=78.8 Åc=47.2 Åß=105.0°1.5 ÅMolecular replacement Kar3 N650KPDB: 1F9UP21a=43.6 Åb=78.0 Åc=47.3 Åß=105.1°1.7 ÅMolecular replacement Kar3 R598APDB: 1F9VP21a=43.9 Åb=77.4 Åc=47.7 Åß=105.9°1.3 ÅMolecular replacement Kar3 E
技术资料暂无技术资料 索取技术资料
