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- 2025年12月05日
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- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
BI 1015550 dihydrate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1340.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥600.0 |
| 规格： | 5 mg | 产品价格： | ￥1256.0 |
| 规格： | 10 mg | 产品价格： | ￥2016.0 |
| 规格： | 25 mg | 产品价格： | ￥3840.0 |
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Nerandomilast dihydrate
MCE 国际站：Nerandomilast dihydrate
产品活性：Nerandomilast (BI 1015550) dihydrate 是一种具有口服活性的 PDE4B 抑制剂，IC50 值为 7.2 nM。Nerandomilast (dihydrate) 具有良好的安全性，在炎症、过敏疾病、肺纤维化和慢性阻塞性肺疾病 (COPD) 中有潜在应用。
研究领域：Metabolic Enzyme/Protease
作用靶点：Phosphodiesterase (PDE)
In Vitro: Nerandomilast (dihydrate) inhibits Lipopolysaccharides (HY-D1056) induced TNF-α release and Phytohemagglutinin P (HY-N7038A) induced IL-2 release in human PBMCs with IC50 values of 35 nM and 9 nM, respectively.
Nerandomilast (dihydrate) inhibits TNF-α release in rat whole blood with an IC50 value of 91 nM.
In Vivo: Nerandomilast (dihydrate) (Example 2) (0, 0.3, 1.0 and 3.0 mg/kg; p.o.; single dose) weakens intestinal transport in rats at 1.0 mg/kg without significantly affecting body weight.
Nerandomilast (dihydrate) prevents inflammation in rat lung tissue with an ED50 value of 0.1 mg/kg.
Nerandomilast (dihydrate) (0.01, 0.1 and 1.0 mg/kg; p.o.; single dose) reduces the Lipopolysaccharides (HY-D1056) induced TNF-α release with dose-dependent manner in mice plasma.
Nerandomilast (dihydrate) (0.1, 0.3 and 1.0 mg/kg; p.o.; single dose) inhibits lipopolysaccharides induced neutrophil entry into bronchoalveolar lavage fluid of male Suncus Murinus and Wistar rats.
Nerandomilast (dihydrate) (2.5 mg/kg and 12.5 mg/kg; p.o.; twice daily for 6 d) effectively improves the damage of Bleomycin (HY-108345) to mice.
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文献和实验bicinchoninate (0.1 g), Na2CO3·H2O (2.0 g), sodium tartrate (dihydrate)(0.16 g), NaOH (0.4 g), NaHCO3 (0.95 g), made up to 100 mL. If necessary, adjust the pH to 11.25 with NaHCO3 or NaOH (see Note 1). 2. Reagent B: CuSO4·5H2O (0.4 g) in 10 mL of water
Use of Biotin-Labeled Probes on Plant Chromosomes
-diaminobenzidine tetrahydrochloride dihydrate (DAB). (A) Localization of ribosomal RNA genes in rye. Two sites are detected (arrows) corresponding with the nucleolar organizers on chromosome 1 (A. Karp, unpublished results). (B) Localization of a B-chromosome
实验试剂 Prepare the following reagents fresh daily except for the citrate buffer. 1. Citrate buffer: Dissolve 23.5 g trisodium citrate dihydrate and 25.5 g citric acid monohydrate in 850 ml distilled water. Check
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