A1874,2064292-12-0

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

A1874

CAS No. : 2064292-12-0

MCE 国际站：A1874

产品活性：A1874 是一种以 nutlin（MDM2 配体）为基础的、BRD4-降解的 PROTAC，DC₅₀ 值为 32 nM (诱导细胞内的 BRD4 降解)。有效抑制多种癌细胞增殖。

研究领域：PROTAC  |  Epigenetics

作用靶点：PROTACs  |  Epigenetic Reader Domain

In Vitro: Treatment of HCT116 cells of A1874 (0-10 μM, 24 hours) induces a dose-dependent knockdown of BRD4 levels, with near-maximum knockdown by 100 nmol/L and a maximum degradation (Dmax) of BRD4 of 98% of the levels in control (0.1% DMSO-treated) cells.
Treatment of HCT116 cells of A1874 (0-10 μM, 24 hours) increases p53 levels in the HCT116 cells and showed dose-dependent p53 stabilization.

相关产品：Bioactive Compound Library Plus  |  (+)-JQ-1  |  Curcumin  |  A-485  |  C646  |  Revumenib  |  BRM/BRG1 ATP Inhibitor-1  |  BI 2536  |  dBET6  |  MZ 1  |  ARV-825  |  Inobrodib  |  Birabresib  |  666-15  |  SGC-CBP30  |  VTP50469  |  ACBI1  |  Vepdegestrant  |  FKBP12 PROTAC dTAG-13  |  AU-15330  |  ARV-771  |  I-BET151  |  dBET1  |  MD-224  |  dCBP-1  |  ABBV-744  |  Anacardic Acid  |  Molibresib  |  NSC 228155  |  KG-501

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds