AZ7550,1421373-99-0

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

AZ7550

CAS No. : 1421373-99-0

MCE 国际站：AZ7550

产品活性：AZ7550 是 AZD9291 的一种活性代谢物，AZ7550 抑制 IGF1R 活性，IC₅₀ 为 1.6 μM。

研究领域：JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK  |  Metabolic Enzyme/Protease

作用靶点：EGFR  |  IGF-1R  |  Drug Metabolite

In Vitro: AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC₅₀s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI₅₀s of 19, 15, and 537 nM, respectively.

相关产品：Osimertinib  |  Trastuzumab  |  Gefitinib  |  Cetuximab  |  Clozapine N-oxide  |  Erlotinib  |  Afatinib  |  Lapatinib  |  AG490  |  Trastuzumab deruxtecan  |  Genistein  |  Neratinib  |  Tucatinib  |  Oseltamivir acid  |  Linsitinib  |  Ceritinib  |  Urolithin A  |  Trastuzumab emtansine  |  Picropodophyllin  |  AG-1478  |  Pertuzumab  |  Dacomitinib  |  Mobocertinib  |  Phosphoramide mustard cyclohexanamine  |  Teriflunomide  |  Mycophenolate Mofetil  |  Disitamab vedotin

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds