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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
AZ7550 trimesylate salt
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2319837-99-3
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3750.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2800.0 |
| 规格： | 10 mg | 产品价格： | ￥4400.0 |
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AZ7550 Mesylate
CAS No. : 2319837-99-3
MCE 国际站：AZ7550 Mesylate
产品活性：AZ7550 Mesylate 是 AZD9291 的一种活性代谢物，AZ7550 抑制 IGF1R 活性，IC50 为 1.6 μM。
研究领域：JAK/STAT Signaling | Protein Tyrosine Kinase/RTK | Metabolic Enzyme/Protease
作用靶点：EGFR | IGF-1R | Drug Metabolite
In Vitro: AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.
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文献和实验8feCjyS3GKGH1QHMapDnb5vQ7vhfJsAE4ibAwkfcfPguE2ACCiUQAj8vXxqxCAavmoIKWSIGV9Y2hoFa6GtlrezQUNZAziyJPTnOjnqb7sI+rHv/l1jRsAU2Zp8N2xN9UCDyJ6P3FalWjo47cWNFVYROKQge99ZjYLc12Dd1Azpdn42ymmGd8V8mwATiIxD5v1h8dfk+E2ACTCCFCYTA34tUChrGqNm4Cepki3k4JTVtaGtpI1eWUB1FzLVS
: 95% 1.5 mmol/L 乙酸铵，5% 乙腈，0.1% 甲酸。 ( 5 ) 溶融石英：100 μm ID X 360 μm OD ( Polymicro Technologies， Phoenix, AZ ) 。 ( 6 ) 反相装填材料：Zorbax Eclipse XDB- C18 5 μm ( Agilent Technologies， PaloAlto ， CA )。 ( 7 ) 阳离子交换装填材料：Poly SulfoethylA ( PolyLC 公司
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