GENZ-882706

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GENZ-882706

CAS No. : 2070864-35-4

MCE 国际站：GENZ-882706

产品活性：GENZ-882706是从专利WO 2017015267A1中提取的有效的集落刺激因子-1受体 (CSF-1R) 抑制剂。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：c-Fms

In Vitro: Genz-882706 induces an increased level of proliferative activity on unstimulated cells 48 hours post treatment and the reason for this effect is unclear.

In Vivo: Daily treatment with Genz-882706 significantly reduces experimental autoimmune encephalomyelitis. Treatment with Genz-882706 in experimental autoimmune encephalomyelitis (EAE) mice results in significant decreases in MCP-1, IL-6, IL-Ιβ and IP-10 levels in spinal cord homogenates when compared to Vehicle treated animals. Treatment with Genz-882706 shows a significant increase in TNF-a levels in the spinal cord when compared to the vehicle treated group. Genz-882706 at both the 30 mg/kg and the 100 mg/kg dose significantly reduces the number of microglia and monocytes/macrophages in the brain and spinal cord compared to the vehicle and LPS controls. Treatment with Genz-882706 modestly reduces CD80 expression on monocytes/macrophages in the brain.

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