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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥934.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥850.0 |
| 规格： | 10 mg | 产品价格： | ￥1360.0 |
| 规格： | 25 mg | 产品价格： | ￥2300.0 |
| 规格： | 50 mg | 产品价格： | ￥3700.0 |
| 规格： | 100 mg | 产品价格： | ￥6000.0 |
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CNX-774
CAS No. : 1202759-32-7
MCE 国际站：CNX-774
产品活性：CNX-774 是具有口服活性的、不可逆的、选择性的 BTK 抑制剂，其 IC50 小于 1 nM。CNX-774 特异性靶向 Btk 的 Cys 481进行共价修饰。
研究领域：Protein Tyrosine Kinase/RTK
作用靶点：Btk
In Vitro: CNX-774 strongly inhibits Btk activity in Ramos cells with an IC50 of 1-10 nM. CNX-774 demonstrates strong time- and dose-dependent occupancy of Btk in Ramos cells.
In Vivo: CNX-774 is stable and non-reactive in fresh human and rat whole blood and does not covalently bond to any of the mid-level abundance human plasma proteins.
CNX-774 demonstrates potent inhibitory activity towards the intended target, Btk, while achieving remarkable specificity in a variety of assays designed to assess off-target reactivity towards abundant cellular thiols and blood proteins.
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文献和实验Measurement of Second Messengers in Signal Transduction: cAMP and Inositol Phosphates
here for measuring the conversion of [alpha?32 P]ATP into [32 P]cAMP after a two?step chromatographic separation. Also critical in signal tranduction is phosphoinositide turnover, which is linked to receptor activation resulting from changes in cytosolic calcium
Control Interferon-alpha treated 4 h 24 h 4 h 24 h ME-15 HuH7 CHF ME-15 HuH7 CHF ME-15 HuH7 CHF ME-15 HuH7 CHF microRNAs rated higher in HuH7 hsa-miR-122a 685 30,912 44.14*** 704 32
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