AZD3229,2248003-71-4

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AZD3229 Tosylate

CAS No. : 2248003-71-4

MCE 国际站：AZD3229 Tosylate

产品活性：AZD3229 Tosylate 是一种有效的、广泛的突变型酪氨酸激酶受体 (KIT) 抑制剂，可用于开发研究胃肠道间质瘤。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：c-Kit

In Vitro: AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI₅₀=1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents.

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