- ￥323 - 1500
- MedChemExpress(MCE)
- 美国
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- 2025年07月09日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
DAS-DFGO-II
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥323.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥850.0 |
| 规格： | 10 mg | 产品价格： | ￥1500.0 |
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UM-164
CAS No. : 903564-48-7
MCE 国际站：UM-164
产品活性：UM-164 (DAS-DFGO-II) 是一种高效的 c-Src 抑制剂，Kd 为 2.7 nM。UM-164 还高效抑制 p38α 和 p38β 活性。
研究领域：Protein Tyrosine Kinase/RTK | MAPK/ERK Pathway | Autophagy
作用靶点：Src | p38 MAPK | Autophagy
In Vitro: In biochemical assays, UM-164 is a highly potent inhibitor of c-Src with a binding constant comparable with Dasatinib (UM-164 Kd=2.7 nM, Dasatinib Kd=0.7 nM). To confirm that UM-164 is capable of inhibiting the activation of c-Src in vitro, the effect of UM-164 is examined on the c-Src autophosphorylation in two TNBC cell lines (MDA-MB 231 and SUM 149). Inhibition of c-Src autophosphorylation is detected in a concentration- and a time-dependent manner. At 120 minutes, complete abrogation of c-Src autophosphorylation is observed at 50 nM, demonstrating that UM-164 is a potent c-Src inhibitor in vitro. Flow cytometry experiments demonstrate that UM-164 treatment of MDA-MB 231 and SUM 149 increased the proportion of G0-G1 cells by 25% and 28%, respectively, and concurrently decreased the fraction of S cells by 16% and 19%, respectively.
In Vivo: A xenograft study is performed using NCr/nude mice implanted with MDA-MB 231 and SUM 149 cell lines. Once the tumors become palpable, the mice are randomized into control and treatment groups. Mice are injected intraperitoneally with either drug (10 and 20 mg/kg in both xenograft studies; a 15 mg/kg dose is added to the SUM 149 xenograft studies) or vehicle every other day (n=5 for each group). At the selected doses of UM-164, there is no significant weight loss or gross abnormalities observed in the treated animals, even after 52 days of treatment. However, tumor growth is significantly inhibited in both the 10 mg/kg and 20 mg/kg dose groups compared with the vehicle-treated group (P<0.026 and P<0.004, respectively).
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文献和实验【求助】文献上细胞给药剂量用10um是10um/ml还是10um/L啊？
haohuaiyong 大家好啊，我现在想用AG490处理细胞，干扰JAK-STAT3信号通路，查了相关文献，有的给药10Um,但是不知道（呵呵，我比较菜），是10um/ml还是10um/L，还请战友帮忙解答一下。 付文献截图 xdb86 人家的m是大写的M，M就是mol/L，10uM就是10×10-6mol/L。uM已经是一个浓度单位了，所以没有你说的：是10um/ml还是10um/L。
锈孢子器 aeci（ di） um 锈菌类（ Uredinales）的生殖器官之一，亦称为锈孢子堆．生于寄主植物组织内．其形状大致呈杯状，顶端突出于寄主体外而开口。其中分化的双核性孢子称为锈孢子。锈孢子为单细胞．多呈广椭圆形、卵形或稜球形，短柄上形成念珠状，表面一般具有小疣，黄褐色或无色，有数个发芽孔。具有发芽管以行发芽，进入夏孢子期或冬孢子期。锈孢子器中，对没有外壁或仅有侧丝包围，而锈孢子仅在寄主体表出现，此称为裸锈孢子器（ caeoma）。
tjmedwnn：请问25uM的氯喹是这样配的吗？？？？大家好，我做质粒转染，说明书上说转染前要加25uM的氯喹。我买的氯喹分子量是515.86，请问大家如果换算成质量这怎么计算啊，是不是25/515.86=0.048μg然后称取0.048μg加进去啊，请大家多教教我，谢谢！丁香园网友szcsyan认为：一般配成stock，浓度高一点。比如25mM。用的时候再稀释。看你买的是多重的。比如X（mg）->； X/515.86 （毫摩）容在Vμl的DMSO（一般用DMSO溶）= 25mM
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