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- 2025年12月05日
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| 规格： | 1 mg | 产品价格： | ￥1238.0 |
|---|---|---|---|
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LEQ506
CAS No. : 1204975-42-7
MCE 国际站：LEQ506
产品活性：LEQ506 是第二代 smoothened (smo) 抑制剂，在人类和小鼠中的 IC50 值分别为 2 和 4 nM。
研究领域：Stem Cell/Wnt
作用靶点：Smo
In Vitro: LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. LEQ506 inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2. LEQ506 is an efficacious compound by consistently decreasing Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and of 60 to 70% for Ptch1.
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文献和实验.51 480.12～538.08 60 513.5 29.18 492.62～534.38 61 476.4 42.06 446.32～506.48 62 511.5 28.46
480.12～538.08 60 513.5 29.18 492.62～534.38 61 476.4 42.06 446.32～506.48 62 511.5 28.46 491.14～531.86 63 480.7 44.83
.18％。男1727例，阳性920例，阳性率53.3％；女1723例，阳性603例，阳性率51％。年龄分组见表1。 表1 年龄分组Hp阳性率 年龄组 检测例数 阳性例数 阳性率（％） ＜20 94 54 57.4 21～30 1029 497 48.3 31～40 979 506 51.7 41～50 547 277 50.6
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