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- MedChemExpress(MCE)
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- 2025年07月10日
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- 详细信息
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
4272-74-6
- 规格：
5 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥440.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥710.0 |
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N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
CAS No. : 4272-74-6
MCE 国际站：N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
产品活性：N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK) 是一种胰蛋白酶样蛋白酶抑制剂，使 HeLa 细胞对 Fas 介导的细胞死亡敏感。
研究领域：Others
作用靶点：Others
In Vitro: N-alpha-Tosyl-L-lysine chloromethyl ketone exhibits an inhibitory effect on IFN-γ activities. The effect of TLCK is studied on the IFN-γ sensitization of HeLa cells towards cell death mediated by anti-Fas. Lower concentration of anti-Fas (10 ng/mL) are used to examine the interaction among the three effectors simultaneously, that is, anti-Fas, TLCK and IFN-γ. TLCK by itself up to 50 μM concentration exhibits a small decrease in cell viability. Beyond 50 μM, a dose dependent decrease in cell viability is observed. IFN-γ slightly reduces cell viability on its own. Addition of anti-Fas (10 ng/mL) results in a slight decrease in cell survival, which is enhanced more than additively in the presence of TLCK, most prominently between 50 and 100 μM. Upon addition of both anti-Fas and IFN-γ, a decrease (≈46%) in cell viability is observed. Moreover, the decrease in cell survival is further enhanced upon addition of higher concentrations of TLCK, 25 μM and more.
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