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-20°C, sealed storage, away from moisture
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货期：1-2天
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10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥6443.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2200.0 |
| 规格： | 5 mg | 产品价格： | ￥5500.0 |
| 规格： | 10 mg | 产品价格： | ￥8500.0 |
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RTI-13951-33 hydrochloride
MCE 国际站：RTI-13951-33 hydrochloride
产品活性：RTI-13951-33 hydrochloride 是一种有效、选择性、可透过血脑屏障的 GPR88 激动剂，在 GPR88 cAMP 功能性实验中，EC50 值为 25 nM。RTI-13951-33 hydrochloride 可以减少大鼠酒精强化和摄取行为。
研究领域：GPCR/G Protein
作用靶点：GPR88
In Vitro: RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 elevates [35S]-GTPγS binding (EC50, 535 nM) in mouse striatal membranes but not in membranes from GPR88 KO mice.
RTI-13951-33 has weak affinities at kappa opioid receptor (KOR; Ki, 2.29 μM), vesicular monoamine transporter (VMAT; Ki, 4.23 μM), and moderate affinity at serotonin transporter (SERT; Ki, 0.75 μM), however, RTI-13951-33 poorly inhibits SERT (IC50, 25.1±2.7 μM).
In Vivo: RTI-13951-33 (10 and 20 mg/kg, i.p.) dose-dependently decreases alcohol lever responses in a rat model of alcohol self-administration.
RTI-13951-33 (10 mg/kg, i.p.) has sufficient brain penetration, with t1/2 of 48 min and 87 min in rat plasma and brain.
相关产品：Bioactive Compound Library Plus | GPCR/G Protein Compound Library | CNS-Penetrant Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | (1R,2R)-2-PCCA hydrochloride | RTI-13951-33 | GPR88 agonist 2 | GPR88-IN-1
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文献和实验Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
Guanidine Hydrochloride Purification of Proteins From SDS PAGE
(Sigma #P7626) 10 ml Pepstatin A (2.0 mg/ml) 10 ml Leupeptin (1.0 mg/ml) 10 ml Aprotinin (5.0 mg/ml) (Protease Inhibitor Cocktail Sigma #P8340) Denaturation Buffer 6 M guanidine hydrochloride 57.3 g G-HCl 20 mM Hepes 7.9 2 ml 1M Hepes pH 7.9 10 mM
Packed column subcritical and/or supercritical fluid chromatography (p-sub or pSFC) has been used as a powerful chiral separation technique, whereby a mobile phase produces low viscosity, a high diffusion coefficient, and a solvating power. P
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