- ￥960 - 1600
- Solarbio
- 北京
- K004409P
- 2025年10月26日
- Rabbit
- Human Mouse Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant protein of human DLAT
- 亚型：
IgG
- 保存条件：
Store at -20°C. Avoid freeze / thaw cycles.
- 克隆性：
单克隆
- 适应物种：
Human Mouse Rat
- 目录编号：
K004409P
- 库存：
999
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 靶点：
DLAT
- 抗体英文名：
Anti-DLAT Polyclonal Antibody
- 抗体名：
DLTA;PDC-E2;PDCE2
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥960.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 单位 | 支 |
| 英文名称 | Anti-DLAT Polyclonal Antibody |
| 别名 | DLTA;PDC-E2;PDCE2 |
| 宿主 | Rabbit |
| 稀释比例 | WB 1:500-2000. IF 1:20-50. |
| Gene ID | 1737 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| Swiss Prot | P10515 |
| 蛋白分子量 | 69kDa |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 亚细胞定位 | Mitochondrion matrix |
| 免疫原 | Recombinant protein of human DLAT |
| 亚型 | IgG |
| 性状 | 液体 |
| 纯化方法 | Affinity purification |
| 背景资料 | This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood. |
| Public Immunogen Range | Recombinant protein of human DLAT |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human Rat Mouse |
| 应用 | WB IF |
| 规格 | 50ul 100ul |
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示：
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with DLAT antibody diluted at 1:1000
Immunofluorescence analysis of HeLa cell using DLAT antibody. Blue: DAPI for nuclear staining.
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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