Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
亚细胞定位
Cell membrane Cytoplasmic vesicle Golgi apparatus Secreted Single-pass type I membrane protein
免疫原
A synthetic peptide of human FGFR2
亚型
IgG
性状
液体
纯化方法
Affinity purification
背景资料
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Public Immunogen Range
A synthetic peptide of human FGFR2
克隆类型
Polyclonal Antibody
交叉反应
Human Rat Mouse
应用
IHC
规格
50ul 100ul
备注:
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
温馨提示:
使用前请离心。如有问题请及时联系我们。
Quick spin before use. If you have any questions, please contact us.
实验图
Western blot analysis with FGFR2 antibody diluted at 1:1000
Immunohistochemistry of paraffin-embedded colorectal cancer��hu�� using FGFR2 antibody at dilution of 1:100 (x100 lens,x200 lens).