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- 2025年07月16日
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文献和实验An In Vitro Transcription Assay for Probing Drug-DNA Interactions During Active Transcription of DNA
Many of the anticancer chemotherapeutic agents in current clinical use are known to interact strongly with DNA (e.g., Adriamycin, cis-platinum, melphalan, mitomycin C, and mitoxantrone). Although the exact mechanism of action remains unresolved
Transcriptional Footprinting of DrugDNA Interactions
binding (e.g., distamycin), formation of adducts or crosslinks (e.g., melphalan, cisplatin, mitomycin C), or by incorporation of modified bases (e.g., 5-fluorouracil, 6-thioguanine). There has therefore been a great effort over many years to establish
What was thought at the time to be a real breakthrough in myeloma therapy came in 1983 when McElwain reported that complete remission could be gained by means of a single, very high, dose of melphalan (HDM). Between 20 and 30
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