- ￥1080 - 87906
- Prospecbio
- 以色列
- pro-2503
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
MCAM
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
2ug/10ug/1mg
| 规格： | 2ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 10ug | 产品价格： | ￥2415.0 |
| 规格： | 1mg | 产品价格： | ￥87906.0 |
CATALOGUE NUMBER
PRO-2503
SYNONYMS
Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18, Cell Surface Glycoprotein MUC18, Melanoma Adhesion Molecule, CD146 Antigen, CD146, Melanoma Cell Adhesion Molecule, S-Endo 1 Endothelial-Associated Antigen, Melanoma-Associated Antigen MUC18, Cell Surface Glycoprotein P1H12, Melanoma-Associated Antigen A32, Gicerin.
INTRODUCTION
Cell surface glycoprotein MUC18 (MCAM), is an integral membrane glycoprotein which is part of the immunoglobulin superfamily. MCAM is related with a variety of carcinomas such as tumor progression, metastasis and is also implicated in embryonic neural development. In Addition, MCAM takes part in cell adhesion, as well as in cohesion of the endothelial monolayer at the intercellular junctions in vascular tissue.
DESCRIPTION
MCAM produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 547 amino acids (24-559 a.a.) and having a molecular mass of 61.0kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).
MCAM is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
SOURCE
Sf9, Insect cells.
PHYSICAL APPEARANCE
Sterile filtered colorless solution.
FORMULATION
MCAM protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
STABILITY
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
PURITY
Greater than 95.0% as determined by SDS-PAGE.
AMINO ACID SEQUENCE
VPGEAEQPAP ELVEVEVGST ALLKCGLSQS QGNLSHVDWF SVHKEKRTLI FRVRQGQGQS EPGEYEQRLS LQDRGATLAL TQVTPQDERI FLCQGKRPRS QEYRIQLRVY KAPEEPNIQV NPLGIPVNSK EPEEVATCVG RNGYPIPQVI WYKNGRPLKE EKNRVHIQSS QTVESSGLYT LQSILKAQLV KEDKDAQFYC ELNYRLPSGN HMKESREVTV PVFYPTEKVW LEVEPVGMLK EGDRVEIRCL ADGN.P.PPHFS ISKQNPSTRE AEEETTNDNG VLVLEPARKE HSGRYECQGL DLDTMISLLS EPQELLVNYV SDVRVSPAAP ERQEG.S.SLTL TCEAESSQDL EFQWLREETG QVLERGPVLQ LHDLKREAGG GYRCVASVPS IPGLNRTQLV NVAIFGPPWM AFKERKVWVK ENMVLNLSCE ASGHPRPTIS WNVNGTASEQ DQDPQRVLST LNVLVTPELL ETGVECTASN DLGKNTSILF LELVNLTTLT PDSNTTTGLS TSTASPHTRA NSTSTERKLP EPESRGAAAL EHHHHHH.
SAFETY DATA SHEET
SDS
USAGE
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文献和实验MCAM produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 547 amino acids (24-559 a.a.) and having a molecular mass of 61.0kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).
MCAM is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Single-Molecule Methods to Study Cell Adhesion Molecules
forces of cell adhesion molecules, which may shed insights on molecular mechanisms of cellular adhesion. In addition, single-molecule techniques enable us to observe the detailed distributions of individual molecular behaviors that cannot be readily
Adhesion Molecule Expression on Cytokine-Stimulated Human Endothelial Cells
Leukocyte adhesion to vascular endothelial cells is central in regulating inflammatory responses. Endothelial cells line the vasculature and cover over 1000 m2 in the average adult (1 ). These cells were long thought to be inert, acting
细胞粘着分子(cell adhesion molecule, CAM)
参与细胞粘着的分子称为细胞粘着分子。 自从N-CAM被发现之后,陆续发现了一些新的细胞粘着分子,如Ng-CAM是神经胶质细胞粘着分子,L-CAM是肝细胞的细胞粘着分子,I-CAM是普遍存在的一种细胞粘着分子,它的配体是LFA-1;而LEC-CAM是白细胞及其它循环细胞中发现的细胞粘着分子。上述细胞粘着分子都是糖蛋白,在细胞外结构域都有与肽共价结合的糖基。根据细胞粘着分子的作用方式可分为三个家族:①免疫球蛋白超家族,如V-CAM、Ng-CAM、I-CAM和L1等;②钙粘着蛋白家族，如E
技术资料