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- pro-521
- 2026年01月16日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
for future use below -18°C
- 保质期：
See instructions
- 英文名：
Filamin
- 库存：
常规产品有备货
- 供应商：
上海经科化学科技有限公司
- CAS号：
无
- 规格：
10ug/50ug/1mg
| 规格： | 10ug | 产品价格： | ￥1080.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2415.0 |
| 规格： | 1mg | 产品价格： | ￥32500.0 |
CATALOGUE NUMBER
PRO-521
INTRODUCTION
DESCRIPTION
SOURCE
PHYSICAL APPEARANCE
FORMULATION
The protein was lyophilized from a 1mg/ml solution containing 20mM Tris / acetate buffer pH 7.6, 0.1mM EDTA, 2mM DTT, 9M urea and 20mM NaCl.
SOLUBILITY
It is recommended to reconstitute the lyophilized Filamin protein at a concentration of 0.5mg/ml in water.
STABILITY
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
PURITY
SAFETY DATA SHEET
SDS
USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
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文献和实验Filamin is a large (270kd) dimeric actin crosslinking protein from a variety of sources, which helps to stabilize the 3D cortical actin network. The fundamental structure of filamin is well conserved and consists of an actin binding domain at the N-terminus followed by a C-terminal rod domain consisting of numerous repeat segments ranging from 4 in C. elegans to 24 in mammalian cells. Each repeat in the rod domain consists of roughly 100 residues and forms an immunoglobulin like fold. Such immunoglobulin folds have been found in a variety of proteins and are responsible for protein-protein interactions. Filamin Human actin-binding protein (ABP), aka filamin, crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Mammalian filamin interacts directly with at least 30 proteins such as transmembrane receptors, second messenger-associated proteins, protein kinases, phosphatases and cytoskeletal proteins and these interactions have been shown to require one or more of the repeat elements in the rod domain.
应力纤维又叫张力纤维，是真核细胞中广泛存在的一种较为稳定的束状纤维结构, 与骨骼肌中肌原纤维非常相像。应力纤维由大量平行排列的肌动蛋白组成,此外还含有其他在肌细胞鉴定过的蛋白质, 包括肌球蛋白Ⅱ、原肌球蛋白、α-辅肌动蛋白和细丝蛋白(filamin), 这些蛋白在肌动蛋白纤维上呈非连续排列, 但肌动蛋白纤维是连续的, 并成双向定向。 应力纤维具有收缩功能。它在细胞的形态发生、细胞分化和组织形成中具有重要作用。由整联蛋白介导的细胞外基质同细胞内的连接也是通过应力
filamentous microorganism|丝状微生物 filamentous phage|丝状噬菌体 filamentous type colony|丝状（型）菌落 filamin|[肌动蛋白]细丝蛋白[可使微丝发生交联] filial generation|子代[亲代所产生的后裔世代] filling|填补（反应） film electrophoresis|薄膜电泳
TRAF‐Mediated TNFR‐Family Signaling
Leonardi, A., Ellinger‐Ziegelbauer, H., Franzoso, G., Brown, K., and Siebenlist, U. 2000. Physical and functional interaction of filamin (actin‐binding protein‐280) and tumor necrosis factor receptor‐associated factor 2. J. Biol. Chem. 275:271‐278
技术资料
