ODN M362-Type C human/murine T

产品信息：CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain an unmethylated CG (Cytosine– guanine) di nucleotide in a specific base sequence (CpG motifs).The p refer to the phosphodiester backbone. These CpG motifs are not seen in eukaryotic DNA are considered pathogen-associated molecular patterns (PAMPs).The CpG PAMP is recognized by (TLR9).3 types of, stimulatory ODNS have been identified based upon immunostimulatory activities. Class A stimulate the production of large amounts of Type I interferons, induce the maturation of pDCs. They are also strong activators of NK cells through indirect cytokine signaling. Class B ODN are strong stimulators of bovine/porcine B cell and monocyte maturation. They also stimulate the maturation of pDC but to a lesser extent than Class A ODN and very small amounts of IFNα. Class C ODN combine features of both types A and B. They contain a complete phosphorothioate backbone and a CpG-containing palindromic motif. They induce strong IFN-α production from DC and B cell stimulation. ODN M362 is a Class C human/murine TLR9 agonist.ODN M362 is a recently identified CpG ODN termed CpG-C that displays both high induction of PDC and activation of B cells. ODN M362 contains a central palindromic sequence with CpG dinucleotides a characteristic feature of CpG-A, and a ‘TCGTCG’ motif at the 5’ end, present in CpGB. The recognition of CpG ODNs is mediated primarily by TLR9