Ovarian Cancer Antigen (CA 125

产品信息：Ovarian cancer Antigen (CA125) is a high molecular weight(>200kDa) mucin-like glycoprotein and is expressed by greater than 80% of nonmucinous epithelial ovarian carcinomas (EOC). This EOC is found in the most serious, endometriod and clear cell carcinomas of ovary(1). Epithelial ovarian cancer (EOC) is the most common cause of death from gynecologic malignancy in the United States and has an over-all 5 year survival rates of less than 30% stages I diseases, 5-year survival rates of 80% to 90% are achieved. The ovarian cancer assay may have the following clinical application: 1. EOC for monitoring tumor growth serum EOC level correlate with clinical disease status in over 90% of cases in which EOC is elevated in preoperative(2) serum sample a rising serum EOC 125 level is therefore, an extremely reliable indicator of recurrent or progressive disease. 2. EOC 125 as a prognostic indicator for ovarian cancer-after cytoreductive surgery and during chemotherapy the level of EOC can provide an early indicator of prognosis(3). 3. EOC might have role as a screening test for the early detection of ovarian cancer.