GKI-1,2444764-03-6

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GKI-1

CAS No. : 2444764-03-6

MCE 国际站：GKI-1

产品活性：GKI-1是Greatwall (GWL)激酶抑制剂，抑制hGWL^FL和hGWL-KinDom的IC₅₀ 分别为4.9 和 2.5 µM。GKI-1 可高效抑制 ROCK1，IC₅₀为11 µM, 仅微弱抑制 PKA。

研究领域：Others

作用靶点：Others

In Vitro: GKI-1 inhibits full-length human GWL, and shows cellular efficacy.

Treatment of HeLa cells (25 and 50 µM, 0-8.5 hours) with GKI-1 reduces ENSA/ARPP19 phosphorylation levels, resulting in a decrease in mitotic events, mitotic arrest/cell death and cytokinesis failure.

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