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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Rat spleen cell glycoprotein
- 亚型:
IgG1
- 形态:
Liquid
- 保存条件:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
- 克隆性:
Monoclonal
- 标记物:
Unconjugated
- 适应物种:
Rat
- 保质期:
12 months from the shipping date of the product.
- 抗原来源:
Rat
- 目录编号:
GTX76264
- 级别:
Primary Antibodies
- 库存:
Available
- 供应商:
GeneTex
- 宿主:
Mouse
- 应用范围:
ICC/IF, IHC-Fr, FACS, IP, ELISA
- 浓度:
1.0 mg/ml (Please refer to the vial label for the specific concentration.)
- 靶点:
Rat RT1a
- 抗体英文名:
MHC Class I RT1A antibody [MRC OX-18]
- 抗体名:
MHC Class I RT1A 抗体 [MRC OX-18]
- 规格:
250 μg
Staining of rat spleen cells with Mouse anti Rat MHC Class I (RT1A) Monomorphic: FITC (GTX76263)
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文献和实验Ovanesov MV et al., J Virol 2006 (PMID:17020949)
目的。挑选出具有亲和力的的 TCR 抗体基因,做随机突变和目的性突变都能够增加 TCR 样抗体亲和力。Chames 等 (2000) 报道,针对肿瘤 T 细胞表位筛选出具有亲和力的 TCR 样本抗体后,在 Fab 做随机突变,通过体外筛选将其亲和力提高了 18 倍。Renner 等(2003)分析 HLA-A2/NY-ESO-1 的 TCR 样 Fab 3M4E5 蛋白结构,确定一些决定亲和力高低的关键氨基酸,在关键氨基酸位点做定点突变,在没有改变 MHC 识别部位的螺旋结构情况下,将 TCR 样
【申请上传】Current Protocols in Immunology
to Visualize Antigen-Specific T Cells Chapter 18 Ligand-Receptor Interactions in the Immune System Introduction Unit 18.1 Binding of Biotinylated Peptides to MHC Class II Proteins on Cell Surfaces Unit 18.2 Detection of Low-Affinity Ligand-Receptor
immune response depends on recognition of foreign antigen presented in the context of MHC class I and class II by professional antigen-presenting cells. Proteins are digested by the proteolytic enzymes of the proteasome. Websites reviewing proteasome
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