Rabbit monoclonal anti-PD-L1 A

gene_symbol：CD274
predicted_size：34 kDa
Uniprot ID：Q9NZQ7
description：Rabbit monoclonal anti-PD-L1 Antibody, clone OR-5H8
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
immunogen：Synthetic peptide within Human PD-L1 C-terminal. The exact sequence is proprietary.
recommended_dilution：IHC: 1:50-1:200
predicted_size：34 kDa
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
host_species：Rabbit
applications：IHC
reactivities：Human