Anti-SHH (Sonic Hedgehog) mous

gene_symbol：SHH
predicted_size：27.6 kDa (Actual 22 kDa/55 kDa)
Uniprot ID：Q15465
description：Anti-SHH (Sonic Hedgehog) mouse monoclonal antibody, clone OTI3A2 (formerly 3A2)
clonality：Monoclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：SHH is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.
immunogen：Recombinant protein expressed in E.coli corresponding to amino acids 24-197 of human SHH
recommended_dilution：WB: 1:2000, IF (1:100)
predicted_size：27.6 kDa (Actual 22 kDa/55 kDa)
buffer：PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
host_species：Mouse
applications：IF, WB
reactivities：Human, Mouse, Rat