Rabbit Polyclonal Anti-TIM3 An

gene_symbol：HAVCR2
predicted_size：Predicted: 33 kDa; Observed: 37 kDa
Uniprot ID：Q8TDQ
description：Rabbit Polyclonal Anti-TIM3 Antibody
clonality：Polyclonal
product_type(primary antibody, secondy antibody ,tag antibody,Loding Control...)：Primary Antibodies
background：The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-? producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).
immunogen：TIM3 antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TIM3. The immunogen is located within amino acids 60 - 110 of TIM3.
recommended_dilution：WB: 1-2µg/mL. IHC: 2µg/mL. Immunoflorescence start at 20µg/mL.
predicted_size：Predicted: 33 kDa; Observed: 37 kDa
buffer：TIM3 Antibody is supplied in PBS containing 0.02% sodium azide.
host_species：Rabbit
applications：IF, IHC, WB
reactivities：Human