- ¥1880 - 2880
- 百奥莱博
- JN1030-PYW
- 北京
- 2025年07月15日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
116
- 英文名：
Recombinant Human Ubiquitin-Conjugating Enzyme E2 Variant 1
- 保质期：
6个月
- 供应商：
北京百奥莱博科技有限公司
- 保存条件：
收到货后请置于-20℃
- 规格：
10μg|50μg|500μg|1mg
特别提示：包括重组人泛素结合酶E2-V1(UBCE2V1)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
产品名称：重组人泛素结合酶E2-V1(UBCE2V1)
英文名称：Recombinant Human Ubiquitin-Conjugating Enzyme E2 Variant 1
产品货号：JN1030
产品规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Ala2-Asn147在C端含有His标签。
UBE2V1质量控制：＞95%(还原性SDS-PAGE)
UBE2V1制剂：液体
UBE2V1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。
关于UBE2V1：
Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family. The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue, rendering it catalytically inactive on its own. However, in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13, which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation. UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Lys63-linked Ubiquitin chain formation. More specifically, UBE2V1 orients the Ubiquitin molecule to favor linkage at Lys63 via a non-covalent interaction with the Ubiquitin molecule. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. UBE2V1 plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6, and TRAF2. It mediates transcriptional activation of target genes. UBE2V1 also controls the progress through the cell cycle and differentiation, the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
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