重组人alpha-1微球蛋白

产品英文名称：
Recombinant Human Alpha-1 Microglobulin

英文简称:
AMBP

中文名称:
重组人alpha-1微球蛋白

背景资料:
Alpha 1-microglobulin （A1M） is a lipocalin superfamily member （kernal lipocalins）. A1M is a low molecular weight protein component of plasma. A1M is distributed in plasma and extravascular compartments of all organs. Alpha-1 Microglobulin is found in mammals， birds， amphibians and fish. The primary sites of A1M synthesis are the liver and the kidney. Around the opening of the lipocalin pocket thrAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. lysyl residues are situated； those residues carry yellow-brown modification derived from the binding and degradation of heme and kynurenin （a tryptophan metabolite）. A1-Microglobulin’s reductase and dehydrogenase have broad biological substrate specificity properties due to its’ frAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. cysteine side-chain which is located in a flexible loop. Alpha-1-microglobulin is glycosylated by thrAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. separate carbohydrate chains: two complex carbohydrates which are N-linked to asparagines at residues 17 and 96， and the other simple carbohydrate which is O-linked to threonine at position 5. The carbohydrates comprise 22% of the total molecular mass of the protein. The glycosylation varies betwAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.n species. A1M exists in two forms- a frAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. form and complexed to other macromolecules: in humans- complexed to immunoglobulin A （IgA）， in rat- complexed to alpha-1-inhibitor-3. FrAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. A1M is exceptionally heterogeneous in charge （therefore also known as protein HC）， and is found tightly linked to a chromophore. The frAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Alpha-1-microglobulin is a monomeric protein composed of one 188 residue polypeptide and contains thrAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. cysteines， two of which （residues 75 and 173） form a conserved intra-molecular disulphide link. The chromophoric group is covalently bound to the frAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. cysteine residue at position 34. A1M binds retinol as a major ligand， but this is probably distinct from its covalent chromophore. Half of all human plasma A1M （approximately 0.03mg/ml） forms a 1:1 complex with about 5% of plasma immunoglobulin A. The resulting macromolecular complexes’ molecular weight is 200000， and a plasma concentration of 0.3mg/ml. The complex can exhibit both antibody activity and a大肠杆菌中重组表达ect many of the biological actions of frAMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Alpha-1-microglobulin. Alpha-1-microglobulin was first discovered in pathological human urine. It was suMGSSHHHHHH SSGLVPRGSH MGPVPTPPDN IQVQENFNIS RIYGKWYNLA IGSTCPWLKK IMDRMTVSTL VLGEGATEAE ISMTSTRWRK GVCEETSGAY EKTDTDGKFL YHKSKWNITM ESYVVHTNYD EYAIFLTKKF SRHHGPTITA KLYGRAPQLR ETLLQDFRVV AQGVGIPEDS IFTMADRGEC VPGEQEPEPI LIPRVested that A1M might be involved in tissue defense against reactive oxygen species， oxidation by heme and kynurenin. Evidence also suMGSSHHHHHH SSGLVPRGSH MGPVPTPPDN IQVQENFNIS RIYGKWYNLA IGSTCPWLKK IMDRMTVSTL VLGEGATEAE ISMTSTRWRK GVCEETSGAY EKTDTDGKFL YHKSKWNITM ESYVVHTNYD EYAIFLTKKF SRHHGPTITA KLYGRAPQLR ETLLQDFRVV AQGVGIPEDS IFTMADRGEC VPGEQEPEPI LIPRVests that A1M functions in the regulation of the immune system. Other functions include: inhibition of stimulation of cultured lymphocytes by protein antigens； induction of cell division of lymphocytes， a mitogenic e大肠杆菌中重组表达ect that can either be enhanced or inhibited by the action of other plasma components； inhibition of neutrophil granulocyte migration in vitro； and inhibition of chemotaxis.

产品描述:
AMBP Human Recombinant produced in E.coli is a single， non-glycosylated polypeptide chain containing 205 amino acids （20-203） and having a molecular mass of 23.1 kDa. AMBP is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MGSSHHHHHH SSGLVPRGSH MGPVPTPPDN IQVQENFNIS RIYGKWYNLA IGSTCPWLKK IMDRMTVSTL VLGEGATEAE ISMTSTRWRK GVCEETSGAY EKTDTDGKFL YHKSKWNITM ESYVVHTNYD EYAIFLTKKF SRHHGPTITA KLYGRAPQLR ETLLQDFRVV AQGVGIPEDS IFTMADRGEC VPGEQEPEPI LIPRV

溶解建议:
提供的重组人alpha-1微球蛋白产品形式为经无菌过滤处理的无色溶液.

保存建议：
重组人alpha-1微球蛋白产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.产品若长期保存，建议添加载体蛋白（0.1% HSA或BSA）.避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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