重组人SGT1蛋白

产品英文名称：
Recombinant Human Signal Recognition Particle 54kDa

英文简称:
SRP54

中文名称:
重组人信号识别颗粒 54kDa

背景资料:
SRP54 is a 54-kDa subunit of the signal recognition particle （SRP）， a cytoplasmic ribonucleoprotein complex which leads the translocation of newly synthesized secretory proteins from the polysome to the endoplasmic reticulum. SRP is composed of six polypeptides and a tRNA-like molecule known as 7SL RNA. SRP54 is a GTP-binding protein that directly binds the signal sequences of nascent secretory and membrane proteins. Anti-SRP autoantibodies take place in patients with an autoimmune chronic muscle inflammation called polymyositis. These auto-antibodies predominantly recognize the SRP54 subunit and in addition are able to immunoprecipitate several of the SRP subunits and the RNA component. Nearly 5% of myositis patients are positive for anti-SRP autoantibodies， increasing to 18% in the subgroup of Jo-1 autoantibody-negative patients. The classic ’anti-SRP syndrome’ is a severe form of polymyositis in which the myositic inflammation is acute and aressive onset， with common myalgias and cardiac involvement. Normally there is a poor reaction to therapy with a 5-year survival rate of about 25%.

产品描述:
SRP54 is a full-length cDNA coding for the human SRP54 protein having a molecular mass of 56，528 Dalton （pH 8.9）. SRP54 protein is fused to a hexa-histidine purification tag.
来源宿主:
Sf9 昆虫细胞重组表达

序列:


溶解建议:
提供的重组人信号识别颗粒 54kDa产品形式为经无菌过滤处理的无色溶液.

保存建议：
重组人信号识别颗粒 54kDa产品在4℃保存请2 - 4周内将使用；-20℃可长期保存.产品若长期保存，建议添加载体蛋白（0.1% HSA或BSA）.避免反复冻融.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。