重组人丝氨酸蛋白酶抑制剂抑制因子B10

产品英文名称：
Recombinant Human Serpin Peptidase Inhibitor， Clade A Member 5

英文简称:
SERPINA5

中文名称:
重组人丝氨酸蛋白酶抑制剂抑制因子A10

背景资料:
SERPINA5 up regulateS TAFI activation by inhibiting the protein C activation. SERPINA5 is an significant regulator in the equilibrium betwSERPINA5 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 408 amino acids （20-406 a.a.） and having a molecular mass of 45.9 kDa. The SERPINA5 is purified by proprietary chromatographic techniques.n coagulation and fibrinolysis by di大肠杆菌中重组表达erentially inhibiting the activation of TAFI and of Protein-C. SERPINA5 belongs to the serpin serine proteinase inhibitor family. SERPINA5 protein inhibits plasminogen activators as well as activated protein C. SERPINA5 is secreted in plasma and liver. SERPINA5 is involved in cell inflammation， proliferation， apoptosis， tumour cell migration， invasion， and metastasis. SERPINA5 controls the invasive potential of renal cell carcinoma by inhibiting urinary plasminogen activator secreted by the cells. SERPINA5 plays a role in regulating key serine proteases involved in metastatic prostate disease. The heparin binding site of SERPINA5 inhibitor is protease-dependent.

产品描述:
SERPINA5 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 408 amino acids （20-406 a.a.） and having a molecular mass of 45.9 kDa. The SERPINA5 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MGSSHHHHHH SSGLVPRGSH MHRHHPREMK KRVEDLHVGA TVAPSSRRDF TFDLYRALAS AAPSQNIFFS PVSISMSLAM LSLGAGSSTK MQILEGLGLN LQKSSEKELH RGFQQLLQEL NQPRDGFQLS LGNALFTDLV VDLQDTFVSA MKTLYLADTF PTNFRDSAGA MKQINDYVAK QTKGKIVDLL KNLDSNAVVI MVNYIFFKAK WETSFNHKGT QEQDFYVTSE TVVRVPMMSR EDQYHYLLDR NLSCRVVGVP YQGNATALFI LPSEGKMQQV ENGLSEKTLR KWLKMFKKRQ LELYLPKFSI EGSYQLEKVL PSLGISNVFT SHADLSGISN HSNIQVSEMV HKAVVEVDES GTRAAAATGT IFTFRSARLN SQRLVFNRPF LMFIVDNNIL FLGKVNRP.

溶解建议:
Sterile Filtered colorless solution. The SERPINA5 solution contains 20mM Tris-HCl buffer pH-8.， 1mM DTT， and 10% glycerol.

保存建议：
SERPINA5 although stable 4℃ for 4 weeks， should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
其他简介：

  ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。